After a severe accident, Cliff Steele wakes up, a changed man, in the house of Dr. Niles Caulder and his Doom Patrol.
The Chief has disappeared and the only clue that the team has to his whereabouts is an average donkey.
The Doom Patrol sets out for Paraguay and discovers Dr. Von Fuchs.
Niles' old friend unexpectedly enlists the Doom Patrol into helping him avert the end of the world.
The Doom Patrol must work with an unlikely ally -- and a pug -- to stop the end of the world.
Jane, Larry and Rita visit a school where Niles' previous team of heroes has retired.
After a violent outburst from Cliff, the team engages in some self-led group therapy.
A sentient, gender-queer, teleporting street, named Danny, is being hunted by the secret Bureau of Normalcy and needs help from Niles.
Jane retreats into a treacherous place in her own mind called The Underground.
Vic and Rita face a dangerous man known as the Beard Hunter, who has been activated by the Bureau of Normalcy to find Niles Caulder.
Larry pays a visit to his long lost-love, while Cliff and Rita travel to Gator Country to reconnect with his daughter.
Silas and the team break into the Ant Farm to rescue Victor.
Rita tries to sooth Victor during a difficult time while the rest of the team finds Flex Mentallo and try to help him regain his memory.
The group prepares for one last stand against Mr. Nobody and rescue the Chief. Victor learns a hard truth.
The team tries to cope with a hard truth as Mr. Nobody prepares for his final act of vengeance.