After a severe accident, Cliff Steele wakes up, a changed man, in the house of Dr. Niles Caulder and his Doom Patrol.
The Chief has disappeared and the only clue that the team has to his whereabouts is an average donkey.
The Doom Patrol sets out for Paraguay and discovers Dr. Von Fuchs.
Niles' old friend unexpectedly enlists the Doom Patrol into helping him avert the end of the world.